Spider-Man: The Sinister Six

You Are Spider-Man. Can You Survive Six Of Your Deadliest Foes?

Marvel Comics Spider-Man: The Sinister Six is the ultimate action-adventure, featuring everyone's favorite wall-crawler. Face down your arch-enemies, The Sinister Six: Dr. Octopus, Hobgoblin, Shocker, Chameleon, Mysterio, and Vulture.

When Spidey's nefarious nasties join forces to frame the Web-Slinger, you must solve puzzles, blast through deadly combat sequences, and fight to save New York. You'll need all of your spider-powers--and all the skills of your alter ego, Peter Parker

Résumé

Spider-Man: The Sinister Six was a PC CD-Rom title from the mid-90's which was similar to many Lucas Arts adventure games.