Kana: Imouto

Kana has a terrible disease and has spent most of her life in and out of the hospital. Takamichi Toudou, her older brother, would do anything to make her well. When he learns the terrible news that Kana can only live another six months at most, his frustration and powerlessness come to a boil. Despite the jealous attention of his girlfriend, Yumi, he starts to experience feelings of romantic love for his sister... especially after he discovers his family's secret. Will he seek for a way to save Kana, or surrender to her destiny, spending the last of their time together?

Résumé

Kana: Imouto is a Japanese PSP game by CyberFront.
One of the most riveting visual novels ever created, Kana ~ Little Sister is a story from the famous Tanaka Romeo, creator of Yume Miru Kusuri and Family Project.